Renal cell carcinoma
Adjuvant therapy in RCC

Isaac (64 years old)

Isaac, a 64-year-old nutritionist with a knack for transforming any meal into a healthy delight, once tried to persuade his grandkids that kale ice cream was the hottest new trend.

Unfortunately, he was recently diagnosed with RCC.

Assessment summary:

  • ECOG PS: 1
  • No relevant comorbidities
  • Thoracoabdominal and pelvic CT scan: centrally located left kidney tumour of 10 cm, extension into vena cava, LN involvement

He underwent radical nephrectomy of the left kidney combined with tumour thrombectomy and removal of 2 enlarged lymph nodes 8 weeks ago.

Pathological findings:

  • pT3bN1 tumour of 11 cm, with extension into vena cava below diaphragm
  • WHO/ISUP grade 4 ccRCC
  • Tumour necrosis present
  • Sarcomatoid features 10%
  • Negative surgical margins

The patient has recovered after surgery and comes to you for check-up. Post-surgery thoracoabdominal and pelvic CT scan: N0M0.

Which of the following options would you choose for this patient?