Bladder cancer

Histological subtypes of (N)MIBC: managed differently compared to pure UCa?

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Educational Objective: Understand the management of invasive urothelial and non-urothelial histological subtypes of non-muscle-invasive (NMIBC) and muscle-invasive bladder cancer (MIBC).
Specialty: Urology (medical oncology, clinical oncology, radiation oncology)
Target Audience: CME (intermediate, advanced), Residents (senior)
Latest update: May 2024

Invasive urothelial and non-urothelial histological subtypes account for up to 25% of all bladder cancers [1]. Nevertheless, current recommendations are mainly based on expert opinion because scientific data on histological subtypes other than pure urothelial carcinoma (UCa) are scarce.

Overview of histological subtypes addressed in this topic according to the 2022 WHO classification of urinary tract tumours [2]

  1. Black AJ and Black PC. Transl Cancer Res 2020;9:6565-75. PubMed 
  2. Netto GJ, Amin MB, Berney DM, et al. Eur Urol 2022;82:469-82. PubMed