Charlotta (43 years old)

Charlotta is a 43-year-old tour guide in Stockholm and loves to show the hidden charms of Sweden’s capital to tourists. Recently, she was diagnosed with early breast cancer following a screening mammography.

Assessment summary

• No relevant medical history or family history of cancer
• Premenopausal, regular menstrual cycles. Nulliparous (G0P0)
• Stage and tumour biology (core biopsy) at diagnosis:
  • cT2N0M0
  • G2, invasive carcinoma of no special type, ER 100%, PgR 90%, HER2 negative (IHC 0), Ki67 25%
• Breast conserving surgery with oncoplastic techniques + SLNB
• Pathology report:
  • G2 bifocal invasive carcinoma, 20 mm largest foci
  • Intermediate grade DCIS 15%
  • Lymphovascular invasion present. No perineural invasion.
  • R0 resection (free margins)
  • 1 involved sentinel lymph node (1/4 sn)
  • pT1c(m)N1a(sn) cM0
• Multidisciplinary board meeting
  • Gene expression profiling: luminal B intrinsic subtype, high risk of recurrence (MammaPrint Index: -0.115; average 10-year risk of recurrence if untreated: 29%)  
  • Adjuvant chemotherapy, followed by RT and endocrine therapy