Bladder cancer
Managing adverse events of systemic therapies in muscle-invasive and metastatic UCaKateryna (80 years old)
Kateryna is an 80-year-old retired elementary school teacher. She enjoys having morning tea on her terrace, hoping to meet some of her former students.
She was diagnosed with muscle-invasive bladder cancer (MIBC) cT3N0M0 and underwent radical cystectomy (RC). The pathological review of the RC specimen indicated pT3 pN0 (0/10) R0, PD-L1 positive.
Assessment summary:
- Medical history: mild hypertension
- ECOG PS: 2
- Peripheral neuropathy grade 1
- No hearing impairment
- GFR: 45 ml/min
- FGFR2/3 mutation status in diagnostic biopsy specimen: wild type
She started adjuvant nivolumab. Approximately 10 weeks after treatment initiation, she developed cough and dyspnoea during active effort, but evaluation did not indicate any infection. C-reactive protein and procalcitonin were within normal range. CT of the chest ruled out pulmonary embolism but identified diffuse ground glass opacities. She was diagnosed with grade 2 pneumonitis.