Breast cancer
UPDATED --- Adjuvant systemic treatment of luminal A/B early breast cancer in premenopausal women

Valeria (43 years old)

Valeria is a 43-year-old trumpeter who loves to play jazz music. Every Saturday, you can find her playing in the local bar with her jazz band. She was diagnosed with early breast cancer following a screening mammography.

Assessment summary

  • Premenopausal
  • No relevant medical history
  • No family history of cancer
  • Stage and tumour biology (core biopsy) at diagnosis:
    • cT2N0M0
    • G2, invasive carcinoma of NST, ER 100%, PgR 90%, HER2 IHC 0, Ki67 15%
  • BCS with oncoplastic techniques + SLNB
  • Pathology report:
    • G2 bifocal invasive carcinoma, 20 mm largest foci
    • Intermediate grade DCIS 15%
    • LVI present, no perineural invasion
    • R0 resection (free margins)
    • 1 macrometastasis (1/4 sn)
    • pT1c(m)N1a(sn) 
  • Multidisciplinary board meeting
    • High risk of recurrence
    • Adjuvant chemotherapy followed by RT and endocrine therapy

Which of the following endocrine treatment options would you choose for this patient?