Breast cancer
NEW --- Systemic therapy for early stage TNBC

Sandra (69 years old)

Sandra, 69 years old, recently started as a volunteer at the local elderly home. The seniors often pour their little hearts out, and she assists them during meals. She already knows most of their grandchildren by name. Sandra recently felt a lump in her left breast.

Assessment summary

  • Postmenopausal
  • No family history of breast or ovarian cancer
  • Medical history: heart failure with reduced LVEF (LVEF at 45%, NYHA class IIB) – treatment with ACE inhibitor, ECOG PS: 1
  • Tumour size: cT1c (16 mm), LN status: cN1
  • Tumour biology:
    • Ductal invasive carcinoma of NST
    • ER 0%, PgR 0%, HER2 IHC 0
    • Ki67 85%
    • G3
  • CT scan chest/abdomen + bone scan: no metastases

Which of the following treatment options would you choose for this patient?