Breast cancer
Brain metastases in patients with HER2+ breast cancerAnna (66 years old)
Anna is a 66-year-old retired nurse. She was diagnosed with HR- HER2+ metastatic breast cancer almost 3 years ago.
- No relevant comorbidities/medical history
- ECOG PS: 1
- First-line treatment for brain and lung metastases:
- SRS of 3 brain lesions
- Paclitaxel + trastuzumab and pertuzumab for 22 months (paclitaxel stopped due to neuropathy after 18 infusions)
- At progression (lung), therapy switched to T-DM1
- 8 months later, progression of 2 of the previously treated brain metastases (mild symptoms) and new lesions of the liver (cytolysis 3x ULN)