Bladder cancer
UPDATED --- Targeted therapies for metastatic UCa in special populations

Stanley (74 years old)

Stanley, 74 years old, has taken up digital art, creating vibrant abstract pieces on his tablet, which he then prints and gifts to friends and family.

He was diagnosed 10 months ago with UCa of the bladder metastatic to the pelvic lymph nodes and lungs and was treated with gemcitabine + cisplatin. The first scan showed a reduced metastatic burden; however, at the end of chemotherapy, the CT scan revealed new and enlarging lung lesions.

The patient started pembrolizumab, but 6 months later he shows again progressive disease.

Assessment summary:

  • Medical history: severe diabetes mellitus (glycated haemoglobin [HbA1c]: 9.5%), hypertension
  • ECOG PS: 1; increasing breathlessness and cough
  • CT scan of chest, abdomen and pelvis: new and enlarged lesions in the lungs
  • FGFR2/3 mutation status in diagnostic biopsy specimen: wild type

The patient is followed up by an endocrinologist for the management of his diabetes and is now well-controlled.

Which of the following options would you choose for this patient?