Lydia (51 years old)

Lydia is a 51-year-old graphic designer. She mainly creates advertisements for companies, but also draws cartoons for a local newspaper on the side. She was diagnosed with breast cancer on the right side following screening mammography.

Assessment summary

• Premenopausal
• Mother died of breast cancer at the age of 54
• No relevant medical history, ECOG PS: 0
• Tumour size: cT2 (28 mm), LN status: cN0
• Tumour biology:
  • Ductal invasive carcinoma of NST
  • ER 0%, PgR 0%, HER2 IHC 0
  • Ki67 60%
  • G3
• Genetic testing: BRCA1 carrier
• CT scan chest/abdomen and bone scan: no distant metastases
• Primary systemic therapy: 4 cycles EC dd + 12 weekly paclitaxel
• BCS + SLNB
• Pathology report:
  • Residual tumour: ductal invasive carcinoma of NST, ER 0%, PgR 0%, HER2/neu IHC 0, Ki67 15%
  • Stage ypT1N0
  • Residual cancer burden: RCB-II