Breast cancer
UPDATED --- Adjuvant systemic treatment of luminal A/B early breast cancer in premenopausal women

Raisa (48 years old)

Raisa is a 48-year-old wedding photographer. Once she won an international prize with 1 of her pictures. She was diagnosed with early breast cancer following a screening mammography.

Assessment summary

  • Premenopausal
  • Medical history: factor V Leiden
  • No family history of breast or ovarian cancer
  • Stage and tumour biology at diagnosis:
    • cT1bN0M0
    • ER 100%, PgR 100%, HER2 IHC 1+, Ki67 10%
  • Upfront BCS + SLNB
  • Pathology report:
    • G1 invasive carcinoma of NST
    • Unifocal, 12 mm, pT1c
    • LVI and perineural invasion absent
    • R0 resection (free margins)
    • pN0 (0/3 sn)
  • Multidisciplinary board meeting: postoperative RT and endocrine therapy 

Which of the following endocrine treatment options would you choose for this patient?