Breast cancer
CDK4/6 inhibitors for everyone? First-line treatment strategies in HR+ HER2- MBC

Juliana (67 years old)

Juliana, a 67-year-old woman, fell on her back during window cleaning. An X-ray showed a suspicious lesion in the spine. A further diagnostic workup was performed, which revealed metastatic breast cancer.

Assessment summary:

  • Postmenopausal
  • No relevant medical history, ECOG PS: 0
  • No family history of breast cancer
  • Imaging:
    • 4 cm tumour in the left breast, 3 suspicious axillary lymph nodes
    • Multiple suspicious lesions in the spine
    • 2 lesions suspicious for metastases in the liver
  • Biopsy of breast and liver lesion: breast cancer, NST, ER 80%, PgR 60%, HER2 IHC 0, G2
  • Haematology and biochemistry: all values normal
  • Germline BRCA-status: wild type

Which option would you choose for this patient?