Prostate cancer
High-risk non-metastatic prostate cancer

Julien (72 years old)

Julien is a 72-year-old retired surgeon who spends most of his time in his garden shed devoting himself to his passion: taxidermy… He is diagnosed with PCa during a check-up.

Assessment summary:

  • Medical history: no relevant comorbidities or medication
  • Life expectancy >10 years
  • Geriatric-8 (G8) score: 15/17
  • ECOG PS: 1
  • PSA: 23 ng/ml
  • Clinical stage (DRE): cT3a
  • mpMRI: PI-RADS 5 lesion lateral right, extracapsular extension, prostate volume 42 ml, no bulky median lobe
  • Prostate biopsy: ISUP grade group 5 (Gleason score 4+5)
  • CT (abdomen/pelvis) + bone scan, or PSMA-PET/CT: no signs of positive LNs or distant metastasis

Which of the following treatment options would you choose as a next step for this patient?