Prostate cancer
Management of non-metastatic castration-resistant prostate cancerAleksander (67 years old)
Aleksander, a 67-year-old music teacher, was diagnosed with PCa some years ago.
Medical history:
- 4 years ago: diagnosis of high-risk PCa (cT2b, biopsy ISUP grade 3 [Gleason score 4+3])
- Treated with RP + ePLND (pT3aN0M0 PCa and negative surgical margins)
- Postoperative PSA 0.03 ng/ml
- 3 years ago: PSA 0.18 ng/ml
- Treated with salvage EBRT, undetectable PSA
- 2 years ago: PSA 1.30 ng/ml (N0M0 on bone scan and CT)
- Treated with ADT, PSA 0.09 ng/ml
- Today: PSA level 4.8 ng/ml, with a PSA-DT of 5 months (serum testosterone 18 ng/dl). The bone and CT scan were negative for metastasis.
He has a history of epileptic absence seizures for which he now receives ethosuximide.