Prostate cancer
Management of non-metastatic castration-resistant prostate cancer

Aleksander (67 years old)

Aleksander, a 67-year-old music teacher, was diagnosed with PCa some years ago.

Medical history:

  • 4 years ago: diagnosis of high-risk PCa (cT2b, biopsy ISUP grade 3 [Gleason score 4+3])
    • Treated with RP + ePLND (pT3aN0M0 PCa and negative surgical margins)
    • Postoperative PSA 0.03 ng/ml
  • 3 years ago: PSA 0.18 ng/ml
    • Treated with salvage EBRT, undetectable PSA
  • 2 years ago: PSA 1.30 ng/ml (N0M0 on bone scan and CT)
    • Treated with ADT, PSA 0.09 ng/ml
  • Today: PSA level 4.8 ng/ml, with a PSA-DT of 5 months (serum testosterone 18 ng/dl). The bone and CT scan were negative for metastasis.

He has a history of epileptic absence seizures for which he now receives ethosuximide.

Which of the following treatment options would you choose for this patient?