Bladder cancer
UPDATED --- New hope for patients progressing after prior treatment for mUCa

Annalisa (71 years old)

Every Sunday, 71-year-old Annalisa prepares an elaborate miniature meal for her hamster Cupcake, turning his Sunday’s dining experiences into tiny culinary adventures…

Unfortunately, Annalisa underwent cystectomy for pT2N0M0 UCa of the bladder. 3 years later, retroperitoneal lymph node metastases were discovered and gemcitabine + cisplatin treatment was started, followed by avelumab maintenance therapy. Now, 14 months after completing gemcitabine + cisplatin, avelumab maintenance is still ongoing but she presents with new metastases.

Assessment summary:

  • Former smoker (50 pack years)
  • Medical history: moderate chronic obstructive pulmonary disease
  • ECOG PS: 1
  • CT scan reveals new and enlarged lesions in the retroperitoneal lymph nodes and new bone lesions
  • GFR: 60 ml/min
  • FGFR2/3 alteration status in metastatic biopsy specimen: wild type

Which of the following options would you choose for this patient?