Magnus (76 years old)

Magnus is a 76-year-old retired firefighter. He has a history of chronic kidney disease associated with hypertension. He initially presented with UCa of the bladder with metastases in the lungs and was treated with gemcitabine + carboplatin. After 6 cycles of chemotherapy, he has now progressive disease.

Assessment summary:

• ECOG PS: 2
• No peripheral neuropathy
• No hearing impairment
• GFR: 35 ml/min
• Haemoglobin: 9.8 g/dl
• CT scan reveals worsening of lung and new liver metastases
• FGFR2/3 mutation status in diagnostic biopsy specimen: activating FGFR3 mutation